Knocking out genes is a technique which researchers and scientists use when the want to find out
which gene is responsible for production of which protein. In a human body there are around 20,500 different genes that each gene is responsible for making a protein because they are known to be the building blocks for different components of the body be it muscles or bones or brain and more. Apparently, our body is made up proteins. Every gene is responsible for producing a different type of protein and the knocking out technique only helps scientists figure out who is responsible for what.
Knocking out a Gene
The scientists first find out genes with some serious mutation or mistake or create one if needed. These genes are dud genes and do not contribute a bit in production of protein. Now, this gene is injected into the DNA of a healthy cell. The scientists attach a tag called reporter gene to it for identification purpose of whether they have been accepted by the cell. Another identification of reporter genes is that the proteins they produce often glow in blue or green. The scientists apparently fool the DNA in a way. A DNA a we know is made up of long strand of genes and these genes can get damaged but the DNA has an inbuilt mechanism to fix the issue. With the help of a cellular tool box the scientist insert the knocked out gene into the DNA. They do this very smartly by making it look like a perfect copy of the surrounding gene that is to be replaced in that DNA. This disguise of sorts fold the DNA repair system and its swaps the dud gene for the old healthy gene, thus knocking out the original gene.
Some times scientists do not have to swap the gene fully. They can simply insert the reporter gene into the DNA they wish to get rid of, randomly. Now, the reporter gene is wedged in the middle of the old gene. Now, there is an all new piece of DNA inside and if a cell goes to read the gene, the instructions would not make sense to the cell due to its presence there. It would not use the gene to make a protein.
The scientist keep a watch on the process. They observe the working in case it is yeast or bacterium but if it is an embryo, scientists observe on how the animal or plant growth differs from other normal ones.
Today, scientists use different techniques to knock out the genes of any organism they want to. It could be mice or bacteria or for that matter even plants that have knocked out genes. Well, scientists today can knock out even human cells growing in the labs.
Rajarajeswari Medical College and Hospital – MOTTO: Availability of medical facilities is of utmost importance. We aim to serve the healthcare requirements needs to the medically unreached population. Through this, we provide quality medical, paramedical, nursing and allied healthcare education, excellent and compassionate hospital services with state of the art facilities as well as to carry out health research for the betterment of the humankind in tune with the holistic values of the institution.
Flu as we all know is a common condition that all of us encounter many a times during our stay on the earth or say our life span. You would rarely find a human who has not been a victim of this health condition. But, there is some good news around this condition. A recent study of a new vaccine containing ancestral flue virus genes is a ray of hope for researchers in the direction of life long protection against flu.
The vaccine was tested on mice and gave 100 percent results. The vaccine was so effective that even after being given nine different flu virus dozes of lethal nature they survived. The best part was they didn’t even fall sick.
Comparatively those mice that were given the traditional shots of flu did fall sick after these lethal doses were given to them and even died. Though, the study is primarily conducted on mice and it would be too early to say how it worked on humans, there is definitely a ray of hope. The hope that one day a universal flu vaccine is developed that would provide long term rather life long protection against flu viruses.
Though even after trying out the researchers still haven’t really succeeded in creating a vaccine that could offer life long protection because of the reason that flu viruses mutate fast. A recent study though used a different approach. The vaccine they created had ancestral and consensus flu genes from four main strain types namely H1 to H5. The delivery of these genes was done using adenovirus, the one responsible for causing common cold but an altered version of it that was harmless and had the ability to carry ancestral genes.
The results as mentioned were affirmative as these mice survived heavy doses of H1N1, H3N1, H3N2 and H5N1 which can easily kill the mice. Apparently 100% of the vaccinated mice survived.
Well, its too early to confirm the success but further study on different animals will certainly help the researchers determine the efficacy of the vaccine in terms of long term protection.
With pollution clogging up the air and chemicals degrading the quality of vegetables and greens, increased stress levels due to constant workloads, early age strokes, accidents while commuting, lifestyle diseases like obesity and more are taking a toll on people. Rehabilitation is slowly and steadily gaining importance in the healthcare sector. These days most of the multi-specialty hospitals have a rehabilitation centre with qualified Physiotherapists for treatment and therapy.
Experts are already forecasting the immense possibilities for expansion and growth of Physiotherapy. The career is definitely a promising one, considering the fact that even people have realized the potential of physiotherapy in significantly improving quality of life by working on body mobilization.
But, before you decide to take your plunge into this field which for sure offers total work satisfaction and is miles away from being monotonous in nature, you need to sit down and think about flip-side of the coin. You need to be aware that this career involves working with people of all ages and mental as well as physical disabilities or challenges. From kids to elderly, mentally challenged to accident victims, general populace to criminals, anyone for that matter could be your patient. Dealing with all kinds of people also means dealing with their tempers. So, primarily you need to have loads of patience and ability to keep calm during stressed times. It is a bit of physical work also because you need to demonstrate the exercises or body moves to the patients. This could be physically draining at times as well. So, take your decision about pursuing the career only after contemplating on these facts.
After giving it a thought, if you still feel passionate about pursuing the career, go ahead. Depending upon your interest you may either go for a Bachelors in Physiotherapy, Masters in Physiotherapy or you many are interested in doing research of taking up teaching as a profession. A doctorate is always advisable. In the US and UK, there is a high demand for Physiotherapists compared to India where the sun seems to be shining on this profession though its only into its initial growth phase. So, taking up a doctorate or a specialization in the field in an overseas university definitely would open doors to umpteen opportunities overseas for this profession. Even the payscale oversees is significantly high compared to India.
In India as a physiotherapist you may get to work in private hospitals, rehabilitation centres, defence establishments, sports and fitness centres, as private consultant to corporates, private practice at your own clinic or with the government hospitals, old age home, mental healthcare centres and more. The work timings are generally good and flexible to an extent. The good part is this profession does not require working during odd hours of the night, etc. So, you get ample time to spend with your family.
Well, Physiotherapy is a challenging field but it is interesting and self satisfying as well. If it interests you a lot and you want to work for serving people and augmenting their health and fitness levels, then this profession is the right choice for you.
Medical education has always topped the list of most sought after career courses in India for decades now. Until a few years back, Medical education was the only course, on the mind of most of the parents for their children – ask any parent about what they want their child to be when he/ she grows up and the common response would be ‘Doctor’. Agreed that now the times are changing slowly and steadily and other
careers particularly the ones that interest the child are taking a front seat, but Medical Education even today is one of the most preferred career amongst all others.
Every year thousands of medical education aspirants toil their hearts out to crack the entrance exams and get themselves the maximum number of choices of reputed medical colleges. Once, the students have cleared their exams and have to choose one college out of the list of colleges available to them, is when they see themselves stuck in horns of the dilemma. Obviously, because it is the question of their career, their life more so. What they choose today is going to decide where they end up in the future. Hence, it becomes very important that you don’t go wrong, as it is like one way traffic. Once you take up the career, you stay on with it most of the times.
If you are also amongst those medical education aspiring candidates, then it is always advisable that you do your groundwork way ahead of taking admission in a medical school. If you already are a star student and are sure enough to crack the entrance in flying colors, make your list of colleges ready so that by the time, its admission time, you are sure on your choice of medical college.
Yes, there are many factors that govern your choice of college, besides your entrance scores. This includes the location of your college, the yearly fees and your personal preferences, irrespective. While, on the hunt for a suitable medical college, you will cross roads with a name synonymous to excellence in medical education. Yes, the name is Rajarajeswari Medical College or RRMCH as it is better known.
One of the best medical colleges in Bangalore, RRMCH is recognized with NAAC A accreditation which automatically certifies its high education standards. Established in the year 2005, with a vision of delivering top notch quality medical education, empowering them to broaden their horizons in the medical arena and contribute as a part or whole in building a healthy and disease free India. For realizing this vision, RRMCH has been offering comprehensive academic programs of international standards.
With a sprawling medical campus and state of the art infrastructure, RRMCH is backed by expert and dedicated faculties who work towards delivering high value education and harnessing the intellectual assets of humankind towards creating future health professionals. RRMCH strongly believes in identifying and enhancing the potential of their students by offering them proper guidance and a powerful knowledge acquisition platform. This is reflected from the facilities it provides to its students including knowledge exchange programs with international medical colleges, active participation in research and innovation programs in the medical science field besides providing interactive sessions with subject specialists and practical experience programs in hospital and research labs.
Obviously, what matters more is your own passion and determination for the medical field and that is what is going to help you shine but if you are looking to carve a career in Medical education, Rajajeswari Medical College and Hospital is one institution you keep on you mind while making your choice of Medical college.
Rajarajeswari Medical college and hospital, RGUHS, Bangalore in association with Medical Education and Learning Point, New Delhi [A division of Quality Council of India] had organized IA & QMS – RRMCH : 2017 from 7th to 10th February 2017 at Kadamba Auditorium, RRMCH, Bangalore. 51 participants from various Medical Colleges & Hospitals in Karnataka, Cochin and Hyderabad had participated.
Bangalore has many Best Medical Colleges, including RGUHS, Bangalore.
Here you see list of top medical colleges in Bangalore.
Rajarajeswari Medical College and Hospital – Bangalore
No.202, Kambipura, Mysore Road,
Vydehi Institute Of Medical Sciences & Research Centre – Bangalore
#82, Nallurahalli, Near BMTC 18th Depot, Whitefield,
St. Johns Medical College, Bangalore
MVJ Medical College and Research Hospital, Bangalore
|firstname.lastname@example.org||Dandupalya, National Highway 4, 30th Km Milestone, Kolathur P.O, Dandupalya, Hoskote, Karnataka 562114|
M S Ramaiah Medical College, Bangalore
|email@example.com||MSR Nagar, MSRIT Post
Bangalore – 560054
Kempegowda Institute of Medical Sciences, Bangalore
|firstname.lastname@example.org||Banashankari 2nd Stage , Bangalore-560070|
Dr BR Ambedkar Medical College, Bangalore
|email@example.com||Kadugondanahalli Bangalore 560045|
Working in the laboratory can be highly stressful. Managing stress effectively is a challenge but it isn’t impossible. Here are a few simple tips for managing stress in laboratory.
Take a Deep Breath – When you are stressed out, breathing does not come so easily to you. So, when you feel you are under stress, just keep aside all your work and take a few deep breaths. Slowly breathe in through your nose, pause for sometime and exhale slowly again through your mouth. Continue to do this a few times and your will see the difference.
Slow & Steady Wins – True to the saying ‘slow and steady wins the race’, in a laboratory, it is essential to go slow and steady in order to reduce the possibility of errors and the stress they are bound to cause. Go slow but steady and you will see your work starts going smooth and error free.
Meditate – Meditation is a great way of reducing stress. There are different types of meditation styles. You can choose the one that you are comfortable with. It could be either meditation with the help of music or without it. Plan and dedicate some time daily for meditation and you will see how it helps you in a couple of weeks. It will not only reduce your stress but make you calm, patient and stronger as a person.
Positive Attitude – Attitude matters and affects everything you do. Every day begin with a positive attitude about a good and stress free day. Even if stress starts building up, stop and realign yourself, think about a positive and fulfilling day and restart work.
Take a short break – This one really works well. While working take a short break after every 2 to 3 hours of work. You can either take a short stroll outside or listen to a soothing song or music or relax. This will rejuvenate you for the coming hours and help keep stress at bay.
Avoid Distractions – With technology bringing information and connections to your pocket or palm, with so many messages, emails and forwards coming in regularly on your phone, it is bound to distract you and not let you concentrate on your work. So, while working as a practice, try stay away from the messages and emails. You may, well, check them when you are taking a break every couple of hours but not as and when they come in. This will not only waste your time but also effect your quality of work.
Follow a hobby – This is not while at work but as a part of your daily routine, try to follow some hobby of yours, be it painting, playing a musical instrument, dancing, gardening, exercise or yoga. Dedicate atleast 30 minutes a day to it and see how it effects your mental health in a positive way.
Try the aforementioned tips and see how they create a positive change in your work life or lab life rather.
Rajarajeswari Medical College and Hospital , Bangalore, Karnataka